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16 Follow-worthy YouTube channels for Affinity tutorials, tips and tricks - Affinity Spotlight.

16 Follow-worthy YouTube channels for Affinity tutorials, tips and tricks - Affinity Spotlight.

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Thank you for visiting nature. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser or turn off compatibility mode in Internet Explorer. In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. We describe a de novo computational approach for designing proteins that recapitulate the binding sites of natural cytokines, but are otherwise unrelated in topology or amino acid sequence.

Our strategy for building hyper-stable de novo mimetics could be applied generally to signalling proteins, enabling the creation of superior therapeutic candidates.

Your institute does not have access to this article. Nature Communications Open Access 05 July Nature Communications Open Access 26 May Nature Communications Open Access 22 March Diffraction images have been deposited in the SBGrid Data Bank with accession numbers and , respectively, and validation reports are included in the Supplementary Information.

Other data and materials are available upon request from the corresponding authors. Akdis, M. Allergy Clin. Smyth, M. Cytokines in cancer immunity and immunotherapy. Lotze, M. In vivo administration of purified human interleukin 2. Half life, immunologic effects, and expansion of peripheral lymphoid cells in vivo with recombinant IL 2. Moraga, I. Synthekines are surrogate cytokine and growth factor agonists that compel signaling through non-natural receptor dimers.

Article Google Scholar. Vazquez-Lombardi, R. Potent antitumour activity of interleukin-2—Fc fusion proteins requires Fc-mediated depletion of regulatory T-cells. Sockolosky, J. Selective targeting of engineered T cells using orthogonal IL-2 cytokine—receptor complexes. Science , — Kureshi, R. Reprogramming immune proteins as therapeutics using molecular engineering. Levin, A. Nature , — Sarkar, C.

Spangler, J. Insights into cytokine-receptor interactions from cytokine engineering. Charych, D. NKTR, an engineered cytokine with biased IL2 receptor binding, increased tumor exposure, and marked efficacy in mouse tumor models. Cancer Res. Dougan, M. Cancer Immunol. Tzeng, A. Antigen specificity can be irrelevant to immunocytokine efficacy and biodistribution.

Natl Acad. USA , — Zhu, E. Synergistic innate and adaptive immune response to combination immunotherapy with anti-tumor antigen antibodies and extended serum half-life IL Cancer Cell 27 , — Kim, D. The sequences of small proteins are not extensively optimized for rapid folding by natural selection. USA 95 , — Taverna, D. Why are proteins marginally stable? Proteins 46 , — Foit, L. Optimizing protein stability in vivo.

Cell 36 , — Marshall, S. Rational design and engineering of therapeutic proteins. Drug Discov. Today 8 , — De Groot, A. Immunogenicity of protein therapeutics. Trends Immunol. Peyvandi, F. Antonelli, G. Eckardt, K. Pure red-cell aplasia due to anti-erythropoietin antibodies.

Treatment-induced antibodies to interleukin Biotherapy 10 , 15—24 Fineberg, S. Immunological responses to exogenous insulin. Boyman, O. The role of interleukin-2 during homeostasis and activation of the immune system. Blattman, J. Therapeutic use of IL-2 to enhance antiviral T-cell responses in vivo. Siegel, J. Interleukin-2 toxicity. Mott, H. The solution structure of the F42A mutant of human interleukin 2. Carmenate, T. Human IL-2 mutein with higher antitumor efficacy than wild type IL Tagaya, Y.

Immunity 4 , — Ozaki, K. Cytokine and cytokine receptor pleiotropy and redundancy. Lin, J. Immunity 2 , — Ma, A. The pleiotropic functions of interleukin not so interleukin 2-like after all. Procko, E. A computationally designed inhibitor of an Epstein-Barr viral Bcl-2 protein induces apoptosis in infected cells. Cell , — Chevalier, A. Massively parallel de novo protein design for targeted therapeutics.

Nature , 74—79 Jacobs, T. Design of structurally distinct proteins using strategies inspired by evolution. Correia, B. Proof of principle for epitope-focused vaccine design. Boyken, S.

   

 

Free Youtube Thumbnails Collection – Simple Video Making



   

This article contains some channels you may already be familiar with, along with some hidden gems we think you should know about. As each YouTube channel offers something unique, they have not been rated in any particular order.

Of course, we had to kick things off with the Affinity YouTube channel—the official place to learn about Affinity Designer, Photo and Publisher. Our videos cover everything from the basics to more advanced step-by-step tutorials, sneak peeks at new features, studio visits with Affinity pro users, Affinity Affinity designer yt free Sessions and other unique content—so be sure to subscribe to stay up to date!

Alongside affinity designer yt free tutorials, Atfinity creates weekly challenges and live streams with reviews of community works to give you the hands-on training you need. With more than tutorials and over 90 live streams, he is one of the most prolific tutorial creators for Affinity Photo on YouTube! Ezra and Ally Anderson both have degrees in education and love to teach using lots of practical examples that anyone can follow along with.

They started Affinity Revolution inand since then, affinity designer yt free added over tutorials to the channel. And even after all that practice, I still have to edit out all of my mistakes!

I make tutorials on YouTube that help people get started with the programs, but we also have in-depth courses on our website courses. Tracey Capone is a talented photographer, illustrator and teacher who shares tons of tips, tricks desigenr other creative goodness on a variety of iPad and desktop apps, including the Affinity Suite.

Affinihy loves working with texture, so expect plenty of advice on how to add texture to your work, as well as tips for carrying out common tasks such as removing the white background from scanned images and placing multiple files at once in Affinity apps. Tracey y shares time-lapse videos of her own artwork to show you what you can create and achieve.

The most popular video on this channel is called Affinity Photo Manipulation iPad Prowhich shows the making of взято отсюда photo composition from start to finish. He created Frankentoon Studio in and since then has been affinity designer yt free free and premium tutorials and нажмите чтобы увидеть больше resources for Affinity Designer, Affinity Photo, Procreate and Affinity Publisher on frankentoonstudio.

His YouTube channel, Frankentoon TV, contains some awesome tutorials and short videos showcasing how to get the most out of his incredible Affinify resources, as well as plenty of workflow insights and tips. These days, due to ongoing health issues, my focus is читать on social media groups and answering questions about workflow and specific tools. However, I am still writing my blog and recording video tutorials, and will be for a while yet.

Affinity designer yt free Fiocco is an illustrator and UI artist based in Brazil. He began his career as a web designer, before moving on to create UI for games. When affinity found himself drawing games assets as well as screens and icons he began to take illustration more seriously.

To break the general notion that vector art is limited to a somewhat flat and graphical style, and to show that you can render artwork in such a way that it feels almost fdee the upside that everything is non-destructible and scalable.

I make sure to showcase all that on my channel by recording time-lapse videos of my process in Affinity Designer, as well as making a series of extensive tutorials affinity designer yt free my affinity designer yt free process from initial sketch to читать больше final render. Isabel Взято отсюда is a designer адрес страницы illustrator from Spain who has been working professionally with digital graphics for decades now.

I felt it would be satisfying to share how I look at things in a simple way to achieve more complexity. A former graphic designer of 10 years, Nick Sapporito now teaches others how to use design software, and he set up the Design Made Simple channel to solve common issues and problems users may be experiencing.

Inhe discovered Affinity Designer, and it ticked all the boxes for his workflow. It gave affinity designer yt free the confidence to create a very complex vector graphic a motorbikeand through that process, I learned a lot about the software.

I decided to upload a tutorial of my design to YouTube in the hope that it might help others, and it was well-received. I create videos for complete beginners to advanced users, and I go at a slow and steady pace so as not to skip over important information.

That allows Affinity afdinity to design along with me. I also include pop up shortcuts, tips and tricks throughout the videos. Jeremy Hazel, aka 7th Season Studio, began his creative career as a tattoo artist before making the jump into digital art.

It contains a variety of tutorials. So in most of them, you will learn how to do really cool things, like changing the entire look of a photo. This year we will be focusing on the business application of Affinity to help users interested in starting a side hustle, such as monetizing services like Print on Похожи autodock download for windows 10 оставляю, going freelance with logo design etc.

Robert Hansford is a teacher and freelance graphic designer who started sharing his creative journey on YouTube around affinity designer yt free year ago. He has always had a great interest in art and began drawing again in his spare affinity designer yt free roughly three years ago. It was then he discovered Affinity Designer for iPad. So, I immediately began to immerse myself in it. I bought it for my iPad first, then my Mac, then I bought Affinity Photo, and later Publisher, and I just started teaching myself how to use all of it.

Vectorize is a channel created by vector aficionado and long-term Affinity user Jhonatan Silva back in Since then, he has posted more than tutorials, from simple drawings to complete projects made with Affinity Designer.

The videos on this channel cater for both beginners and professionals and incorporate a variety of art styles and vector tools designef solutions, so there really is something for everyone.

Jhonatan also runs a design school community called Vectorize club. Visit the vectorizeclub. Mani Singh is a self-taught designer and illustrator from India who creates a wide fafinity of work in Affinity Designer, including logos, illustrations, brochures and banners.

He also likes to experiment with photo manipulation, but the majority of his videos are focused on graphic design and illustration. Mani started his YouTube channel Design Art Studio to showcase his work and share his own techniques and experience to help others.

Yg videos showcase how he creates projects from start to finish in real-time. Some contain voice narration, but most simply have background music playing over the top. We no longer support Internet Explorer. Please upgrade your browser to improve your experience. Find out more. About Contact. If you want to learn the ins affinity designer yt free outs of Affinity software and boost your creative skills, there are countless YouTube channels to teach affinity designer yt free.

But with so much choice, it can seem difficult to know where to fres. Please turn on JavaScript to view this video.



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